The increasing regulatory requirements to which biological agents are subjected will hopefully have a great impact in the fields of industrial protein expression and production, live vectors for bio-therapeutic agent delivery and gene therapy. In this particular context, the problem can show two distinct facets: The antibiotic molecule itself, seen as a contaminant product in a given biological and the antibiotic resistance gene used as a selection marker. Besides therapeutic applications, antibiotics are often used as a selection pressure to avoid bio-contamination in production processes such as fermentation. The improvement of existing antibiotics and discovery of new molecules is, by definition, an endless quest. The first consequence is the emergence of resistant or even multi-resistant pathogenic bacterial strains that has become a general concern promise to even further increase.

Unfortunately, the excessive and sometimes inappropriate use of antibiotics is responsible for a large-scale spreading of antibiotics in the environment. The discovery of antibiotics, considered for several decades a major step forward in the global domain of therapy against some infectious agents, is still a very active domain of investigation.

Ccda install helpx